I love Twitter for Mac. One of the great things about it is gesture support for navigation. Since I use a 27” iMac I found that I would often scroll on the Twitter window even though it wasn’t active and I couldn’t use gestures. Sure it was just one click to make Twitter the frontmost window, but you can use this boolean to do it automatically.
defaults write com.twitter.twitter-mac ScrollingMakesKeyAndOrdersFront -bool trueWhen you scroll on the Twitter window it will automatically bring it to the front so your gestures are active.